Emanuela Tolosano Selected Research

Heme (Haem)

2/2022	Inhibition of Heme Export and/or Heme Synthesis Potentiates Metformin Anti-Proliferative Effect on Cancer Cell Lines.
1/2022	Hemopexin and Cancer.
1/2022	Divergent roles of haptoglobin and hemopexin deficiency for disease progression of Shiga-toxin-induced hemolytic-uremic syndrome in mice.
10/2021	Endothelial Heme Dynamics Drive Cancer Cell Metabolism by Shaping the Tumor Microenvironment.
1/2021	HEME: a neglected player in nociception?
1/2021	The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation.
5/2020	Hereditary Ataxia: A Focus on Heme Metabolism and Fe-S Cluster Biogenesis.
1/2020	Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases.
12/2019	Heme and sensory neuropathy: insights from novel mutations in the heme exporter feline leukemia virus subgroup C receptor 1.
1/2019	The Multifaceted Role of Heme in Cancer.

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Emanuela Tolosano Research Topics

Disease

12	Neoplasms (Cancer) 02/2022 - 02/2017
12	Hemolysis 01/2022 - 12/2002
6	Inflammation (Inflammations) 01/2022 - 04/2002
5	Colorectal Neoplasms (Colorectal Cancer) 02/2022 - 02/2017
3	Fibrosis (Cirrhosis) 01/2022 - 12/2002
3	Infections 01/2022 - 04/2011
3	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 12/2002
3	Hypoxia (Hypoxemia) 01/2020 - 01/2013
3	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2018 - 10/2009
3	Sickle Cell Anemia (Hemoglobin S Disease) 01/2018 - 03/2013
3	Anemia 06/2014 - 01/2013
2	Pain (Aches) 01/2021 - 12/2016
2	Carcinogenesis 01/2020 - 01/2019
2	Liver Diseases (Liver Disease) 01/2020 - 08/2010
2	Stroke (Strokes) 01/2019 - 05/2009
2	Cerebral Hemorrhage 01/2019 - 02/2016
2	Bacterial Infections (Bacterial Infection) 02/2017 - 01/2013
2	Sepsis (Septicemia) 02/2017 - 04/2011
2	Thalassemia 01/2016 - 03/2013
2	Iron Overload 05/2015 - 06/2014
2	Rupture 01/2013 - 12/2002
1	Cholestasis 01/2022
1	Disease Progression 01/2022
1	Hemolytic-Uremic Syndrome 01/2022
1	Thrombotic Microangiopathies 01/2022
1	Chronic Pain 01/2021
1	Ataxia (Dyssynergia) 05/2020
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 05/2020
1	Friedreich Ataxia (Friedreich's Ataxia) 05/2020
1	Spinocerebellar Degenerations (Marinesco Sjogren Syndrome) 05/2020
1	Posterior column ataxia 05/2020
1	X-linked sideroblastic anemia 05/2020
1	sideroblastic spinocerebellar ataxia Anemia 05/2020
1	Neoplasm Metastasis (Metastasis) 01/2020
1	Prostatic Neoplasms (Prostate Cancer) 01/2020
1	Hereditary Sensory and Autonomic Neuropathies (HSAN) 12/2019
1	Vascular Remodeling 06/2019
1	Gliosis 01/2019
1	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2018
1	Posterior column ataxia with retinitis pigmentosa 10/2017
1	Body Remains 02/2017
1	Citrullinemia 01/2017
1	Hyperammonemia 01/2017
1	Perinatal Death 01/2017
1	Cardiotoxicity 01/2017
1	Brain Injuries (Brain Injury) 02/2016
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2016
1	Erythropoietic Porphyria (Congenital Erythropoietic Porphyria) 06/2014
1	Sideroblastic Anemia 06/2014
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/2013
1	Hypertension (High Blood Pressure) 01/2013
1	Thrombosis (Thrombus) 01/2013

Drug/Important Bio-Agent (IBA)

31	Heme (Haem)IBA 02/2022 - 07/2008
11	HemopexinIBA 01/2022 - 12/2002
11	IronIBA 01/2021 - 04/2005
7	Hemoglobins (Hemoglobin)IBA 01/2022 - 11/2005
7	Proteins (Proteins, Gene)FDA Link 08/2021 - 04/2002
6	HaptoglobinsIBA 01/2022 - 12/2002
3	Pharmaceutical PreparationsIBA 01/2022 - 01/2018
3	RNA-Binding Proteins (RNA-Binding Protein)IBA 08/2021 - 02/2017
2	EnzymesIBA 02/2022 - 01/2019
2	Ferritins (Ferritin)IBA 01/2022 - 10/2009
2	Heme Oxygenase-1IBA 01/2022 - 07/2008
2	Adenosine Triphosphate (ATP)IBA 06/2019 - 04/2011
2	Oxygen (Dioxygen)IBA 01/2018 - 01/2014
2	PorphyrinsIBA 06/2014 - 01/2014
2	phenylhydrazine (phenylhydrazine hydrochloride)IBA 05/2014 - 07/2008
2	Acute-Phase Proteins (Acute-Phase Protein)IBA 12/2013 - 04/2002
1	AcidsIBA 02/2022
1	Metformin (Glucophage)FDA LinkGeneric 02/2022
1	Small Interfering RNA (siRNA)IBA 02/2022
1	Shiga Toxin (Shigella Toxin)IBA 01/2022
1	CollagenIBA 01/2022
1	MicroRNAs (MicroRNA)IBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	AgarIBA 08/2021
1	CalciumIBA 06/2019
1	ProstaglandinsIBA 01/2019
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2019
1	Complement System Proteins (Complement)IBA 01/2018
1	Interleukin-22 (IL-22)IBA 02/2017
1	CytokinesIBA 02/2017
1	CitrullineIBA 01/2017
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2017
1	AntioxidantsIBA 01/2017
1	DNA (Deoxyribonucleic Acid)IBA 01/2017
1	Urea (Carbamide)FDA LinkGeneric 01/2017
1	Tocopherols (Tocopherol)IBA 01/2017
1	Therapeutic UsesIBA 01/2017
1	heme oxygenase-2IBA 02/2016
1	stroma free hemoglobinIBA 02/2016
1	Transferrin (beta 2 Transferrin)IBA 05/2015
1	CytochromesIBA 05/2014
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2013
1	Vasoconstrictor AgentsIBA 01/2013
1	Vasodilator Agents (Vasodilators)IBA 01/2013

Therapy/Procedure

4	Therapeutics 10/2021 - 08/2010
2	Ligation 01/2022 - 04/2011
1	Liver Transplantation 01/2020